The sample can then be introduced to the LC column where the molecules separate based on their size (size exclusion chromatography), affinity to stationary phase (affinity chromatography), polarity (ion exchange chromatography), or hydrophobicity (reversed phase chromatography). Typical LC/MS experiments include several analytical stages, starting with sample pre-treatment which commonly includes sample cleanup and extraction methods. broad screening of biomolecular components across multiple samples (corresponding to different conditions, interventions, or time points) in order to elucidate the observed phenotypes or discover biomarkers. In this context, the technology has been increasingly utilized for differential profiling, i.e. Liquid chromatography coupled to mass spectrometry (LC/MS) has been widely used in proteomics and metabolomics research.
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